2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120925
    TRV0109101 1401027-29-9 98%
    TRV0109101 is a μ-opioid peptide receptor (MOPR) selective agonist (KD = 70 nM) with blood-brain barrier permeability. TRV0109101 selectively promotes G protein signaling pathway coupling while reducing the recruitment of β-arrestin. TRV0109101 inhibits opioid-induced mechanical hyperalgesia and induces antinociceptive tolerance. TRV0109101 is applicable for pain-related research.
    TRV0109101
  • HY-120928
    S 16474 149250-10-2 98%
    S 16474 is a cyclic peptide with antagonistic effects on NK1 and NK2 receptors. S 16474 can be used in the study of neurogenic inflammation.
    S 16474
  • HY-120935
    (R)-Dabelotine 152886-02-7 98%
    (R)-Dabelotine is the R-isomer of Dabelotine and functions as an adrenergic agonist, making it valuable in dementia research.
    (R)-Dabelotine
  • HY-120938
    JYL-273 analog-1 289902-71-2 98%
    JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM). JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED50 = 1.0 mg/kg). JYL-273 analog-1 can be used for analgesia studies.
    JYL-273 analog-1
  • HY-120939
    S14063 137289-83-9 98%
    S14063 is a potent 5-HT1A receptor antagonist. S14063 is devoid of β-adrenoceptor blocking properties.
    S14063
  • HY-120945
    PDE10A-IN-1 1354404-30-0 98%
    PDE10A-IN-1 is a phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 250 nM and the ability to cross the blood-brain barrier. PDE10A-IN-1 can be used in research on neurological disorders such as schizophrenia.
    PDE10A-IN-1
  • HY-120946
    VMY-2-95 1434047-61-6 98%
    VMY-2-95 is an oral active and blood-brain barrier (BBB) penetrant α4β2 nicotinic acetylcholine receptor desensitizer. VMY-2-95 can be used for study of depression or addiction.
    VMY-2-95
  • HY-120985
    Araguspongin B 123000-02-2 98%
    Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
    Araguspongin B
  • HY-121001
    Amanozine 537-17-7 98%
    Amanozine (Compound 15) is a 5-HT3 serotonin receptor agonist. Amanozine is promising for research of nervous system disorders.
    Amanozine
  • HY-121041
    GEBR-7b 1776944-03-6 98%
    GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits.
    GEBR-7b
  • HY-121053
    Adatanserin 127266-56-2 98%
    Adatanserin (WY-50324) is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin shows significant anxiolytic and antidepressant activity in an animal conflict model.
    Adatanserin
  • HY-121080
    AMG8163 659731-59-6 98%
    AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448)-induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models.
    AMG8163
  • HY-121097
    Diapocynin 29799-22-2 99.0%
    Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.
    Diapocynin
  • HY-121129
    Eticlopride 84226-12-0 98%
    Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent.
    Eticlopride
  • HY-121130
    Dacuronium 43021-45-0 98%
    Dacuronium (17-hydroxypancuronium) is a steroid muscle relaxant.
    Dacuronium
  • HY-121141
    Adiphenine 64-95-9 98%
    Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects.
    Adiphenine
  • HY-121143
    Bis-Q 73711-18-9 98%
    Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially..
    Bis-Q
  • HY-121146
    Chinotilin iodide 56583-56-3 98%
    Chinotilin (iodide) serves as an antagonist for muscle relaxation.
    Chinotilin iodide
  • HY-121155
    AD11 74670-75-0
    AD11, a sulfonamide derivative, exhibits anticonvulsant potency in the rat.
    AD11
  • HY-121164
    GSK172981 1133705-99-3 98%
    GSK172981 is a brain-penetrant tachykinin NK3 receptor antagonist with pKi values of 7.7 and 7.8 for human and native guinea pig NK3 receptors, respectively. GSK172981 can be used for the study of schizophrenia.
    GSK172981
Cat. No. Product Name / Synonyms Application Reactivity